In this episode we will look at the sensation of itching and how it is perpetuated. What is the difference between an acute itch vs. chronic itch? How are skin cells, neurons and immune cells talking to each other? Why do we itch? And how does itching fit into the larger phenomena of...
How is cholesterol metabolized? What controls its biosynthesis? What happens when it’s modified? What are the effects of oxidized cholesterol on health and disease? What about cholesterol immunometabolism? Check out this episode to learn more.
Fatty liver disease is the most common chronic liver disease globally. Who is at higher risk? How is this related to cargo exchange between the liver and fat tissue? How is this related to Vitamin A? We’ll look at lesser known facts on fatty liver disease in this episode.
What are some factors involved in the development of Alzheimer’s Disease? ApoE4 increases the risk of AD but how? What is the difference between brain ApoE and peripheral ApoE? What’s the connection with microglia?
Lots of dance at this time of year with many friends having their shows. Bolt by Jeryl Palana’s Art on Earth company started off Asian American Month with a focus on three women choreographers. I had a blast watching them and moderating the Q&A afterwards. Such wonderful artists! And...
Human ApoE has three isoforms differing only by 1 amino acid substitution at either position 112 or 158, resulting in E2, E3, or E4 alleles. Even 1 copy of the E4 allele raises your risk for Alzheimer’s Disease 4-fold and if you’re unfortunate enough to possess an E4 allele...
What are HDLs? Are they cardioprotective or harmful? How do statins affect them? How do they impact immune cells? Join us for this episode of vlmd rounds and learn about HDLs–the truth may surprise you.
We’ll look at the Renin-Angiotensin-Aldosterone System (RAAS) and its impact on different tissues in the body with an emphasis on the brain. Find out how RAAS activation damages your body and what to do about it.
BCAAs have been implicated in obesity, insulin resistance, worsening heart failure and liver disease. Should we be cutting down on BCAAs? Are plant protein sources better for you? Why do I consider this topic a can of worms (which, incidentally, are a great source of protein and BCAAs!)...
It’s important to know when ketones are good for you and when they are bad for you. What do we know about heart function on chronic ketone body exposure? What do ketones have to do with mTORC1 and v-ATPases? How did amino acids sneak into this episode??? Check out Episode 30 of vlmd...
